PROTOCOL: OPTIMIZE

Your protocol, built from the research.

For the human committed to their highest evolution. Pick what you want to optimize. Walk away with the labs to run, the interventions with published support, and the questions to bring to your doctor — every recommendation sourced.

Start OPTIMIZE →

$147 one-time · all domains · owned forever

What you walk away with

The answer to: what should I actually do?

Every intake ends in three concrete deliverables. Specific. Sourced. Yours to act on.

YOUR PROTOCOL · V.1.3 deterministic · cited LABS TO RUN Z.01 · to order total T ng/dL SHBG · free T · E2 nmol/L · pg/mL LH · FSH mIU/mL morning draw · fasted SELF-DIRECTED Z.02 · what to take ashwagandha root 600 mg AM magnesium glycinate 400 mg PM zinc picolinate 30 mg AM OTC · dosed from studies · cited ASK YOUR DOCTOR Z.03 · clinician “TRT appropriate for me?” “enclomiphene over clomid?” “thyroid panel worth adding?” Rx options · evidence-backed
01 — The labs to run

Measure what will change your decisions.

Every biomarker in your panel has a decision riding on it — what you’ll do differently based on the result. The protocol tells you the ones that move the needle for your goal, and which results mean which next move.

02 — What to take, starting now

Real evidence. Real doses. No Reddit guesswork.

The interventions with published support, organized by effect size, at the doses actually used in studies. Everything you can legally self-administer — clearly separated from what you can’t.

03 — What to ask your doctor

The prescription options you never hear about.

The pharmaceutical options your clinician may not bring up unprompted — with the exact questions, studies, and talking points to take to the appointment. You walk in informed.

The evidence we route

Effect sizes from the studies, not the forums.

Every recommendation is sourced. Three representative examples of what routed protocols rest on:

CORPUS pubmed · cochrane meta-analyses N · RAW FILTER V.1 · WEIGHTED ✗ EXCLUDED Z.01 · T +17% ¹ Z.02 · SLP −17 min ² Z.03 · LNG +14% ³

¹²³Effect sizes are reported ranges from the cited literature. PROTOCOL: OPTIMIZE surfaces the evidence; you and your clinician decide what to run. Not every compound has studies this strong — where the evidence is thinner, the protocol says so.

Up to +17%1

Serum testosterone.

Reported range across randomized trials of standardized ashwagandha root extract (8–12 weeks) in adult men.

→PubMed
Up to −17min2

Sleep onset latency.

Reported reduction from RCTs of oral magnesium supplementation in adults with sleep complaints.

→PubMed
Reported +14%3

Median lifespan, rapamycin in mice.

Reported from the NIA Interventions Testing Program in genetically heterogeneous mice, late-life dosing.

→PubMed

Pick what you want to fix

Five domains at launch. More coming, free.

Each domain has its own intake, its own evidence database, and its own protocol output. Run one. Run all five. Your call.

T.01

Testosterone

Hormonal optimization for any biology. Natural and clinical pathways.

SLP.02

Sleep

Architecture, latency, depth, circadian alignment

COG.03

Cognition

Focus, memory, processing speed, neuroprotection

BDC.04

Body Comp

Lean mass, fat loss, metabolic flexibility

LNG.05

Longevity

Senolytics, NAD+, mTOR, biological age reduction

Methodology

How we decide what’s in the protocol.

Every recommendation traces to a citation. Every citation was judged by study type. The engine weights evidence by source tier before routing it to your intake.

Where the evidence is thin, the protocol says so. You see the tier. You decide.

Evidence tiers Routing weight
T.01 Meta-analysis / Cochrane review
T.02 Randomized trial in humans
T.03 Cohort, animal, or mechanistic
T.04 Preliminary or single small trial

Blog posts, forum threads, and unsourced claims do not enter the database.

How you use it

Under ten minutes to a real plan.

01

Pick what you want to optimize

Testosterone, sleep, cognition, body comp, or longevity. Start with the one that’s been nagging you.

02

Answer the intake

Symptoms, goals, baselines, contraindications — checkbox questions that map directly onto what actually changes the plan.

03

Get your protocol

The labs to run. The interventions with real evidence. The questions to bring to a clinician. All sourced. Yours to act on today.

What you get

Everything for $147. Once.

One payment. You own this version forever. All future domains included for existing owners.

+ All 5 optimization domains
+ Future domains at no extra cost
+ Intervention + biomarker tracking
+ Cited sources for every intervention
+ Charts over your own logged data
+ $147. Lifetime.

The math

Less than one clinic visit. Works for every domain. Forever.

Alternative Their price PROTOCOL: OPTIMIZE
Longevity consultation $300–500/visit $147 once
Online TRT clinic workup $200–400 + monthly $147 once
Supplement coach $200/month $147 once
Reddit + PubMed rabbit holes Free but hours $147 once

What this is

Explicit about scope.

× Evidence direct. Surfaces what PubMed says about your specific situation. You decide what to do with it.
× A map, not a doctor. Tells you clearly when a licensed clinician is the right next step.
× Deterministic. Rule-based routing over structured PubMed evidence. Traceable. Auditable.
× No more gatekeepers. The evidence reaches you unmediated by a human oracle.

Questions

What you probably want to know.

The compound database is reference material you can browse for free. PROTOCOL: OPTIMIZE is the intake system that routes your specific answers to specific interventions, generates a protocol split into what you can do yourself and what needs a clinician, and tracks your progress over time.
No. PROTOCOL: OPTIMIZE uses deterministic rule-based routing over structured evidence from PubMed. Your intake answers route through decision logic to specific interventions. No LLM, no chatbot, no generated content. Every output is traceable to the evidence that produced it.
$147 one-time. You own it. Future domains are included for existing owners at no extra cost.
It tells you what the published evidence supports for your specific goal and situation, clearly separated into what you can legally do yourself and what needs a clinician’s sign-off. You decide.
At launch: testosterone, sleep, cognition, body composition, and longevity. More domains will be added and are included for existing owners at no additional cost.
Less than one longevity consultation ($300–500). Less than one month of an online TRT subscription. Less than one month of supplement coaching ($200/month). And you own it forever.
The intake screens for red-flag symptoms. If you check any, the tool routes you to see a clinician before any optimization content is shown. That is standard clinic intake protocol.

Stop guessing. Start optimizing.

Five domains. One intake each. A real plan you can act on today — every recommendation sourced. $147 once, owned forever.

ONE-TIME

$147

Start OPTIMIZE →

$147 one-time · instant access · lifetime · owned forever

Built by Protocols.is — sovereignty infrastructure for the prototype.